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OBJECTIVE:To optimize the formulation of Dimemorfan phosphate tablets. METHODS:Using 60 min dissolution rate of dimemorfan phosphate as index,L9(34) orthogonal test was used to optimize the amount of starch,microcrystalline cellu-lose,croscarmellose sodium and concentration of HPMC E5 solution. The friability,hardness,60 min dissolution rate and main component were detected. The similarity of dissolution curves of Dimemorfan phosphate tablets was compared with that of imported tablets in 0.1 mol/L hydrochloric acid,pH 6.8 phosphate buffer,water and pH 4.0 acetate buffer. RESULTS:The optimized formu-lation of Dimemorfan phosphate tablet(1 000 tablets)was composed of dimemorfan phosphate 10 g,starch 60 g,microcrystalline cellulose 40 g,10% HPMC E5 solution and croscarmellose sodium 25 g. The friability,hardness,60 min dissolution rate and main component of 3 batches of Dimemorfan phosphate tablets prepared by optimized prescription were 0.42%-0.58%,9.8-10.5 kg,94.89%-96.21% and 99.21%-99.52%,respectively. In 4 dissolution mediums,similar factors f2 of dissolution curves between prepared tablets and imported tablets were above 50. CONCLUSIONS:Dimemorfan phosphate tablets were prepared successfully. The optimized formulation is rational. The dissolution behavior of prepared tablets is similar to that of imported tablets in vitro.
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Objective:To establish a method for the determination of dichloromethane, methanol and ethanol in fenticonazole ni-trate. Methods:The samples were detected by headspace GC. The column was OV-1301(30 m × 0. 53 mm,3. 0 μm), the detector was FID with nitrogen as the carrier gas, the detector temperature was 250 ℃ and the injector temperature was 200 ℃. Results:The linear range of dichloromethane, methanol and ethanol was 2. 436-21. 924(r=0. 998 8), 12. 268-110. 412(r=0. 999 5) and 20. 052-180. 468 μg·ml-1(r=0. 996 9) with the average recovery of 99. 30% (RSD=2. 36%), 100. 21%(RSD=1. 07%) and 100. 15%(RSD=1. 21%)(n=9), respectively. Conclusion:The detection method is sensitive, accurate and reliable, and can be used in the quality control of fenticonazole nitrate.
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Objective To investigate the psychological measurement index for the effectiveness and discrimination of drug packaging (color code) in the medicine for self-aid and mutual-aid .Methods The classical priming paradigm was used to inves-tigate whether there were influences on the recognition accuracy (ACC) and reaction time (RT) by memorizing the characteris-tics of three series of color code ,with a 2 (relevant or irrelevant priming )× 3 (color code categories) within subject experimen-tal design .Results ①The recognition (RT ) of the relevant-priming group was 1 387 .18 ms ,compared with the irrelevant-priming group 1 475 .12 ms .The independent two-sample t-test showed statistically significant difference between the relevant-priming and irrelevant-priming groups (t=2 .264 ,P=0 .02) .②The analysis of variance of factorial design showed a significant difference among the three series in the recognition (RT) (F=9 .945 ,P<0 .001) .The priming effect was significant in color code 1 and 3 ,while not significant in color code 2 .③The recognition (RT) in color code 2 was different by the judgment task :using directives< class-1 categorical attributes < class-2 categorical attributes ,consistent with the order of difficulty of the judgment task .The P value for the priming effect was 0 .03 ,0 .21 and 0 .7 in the judgment task for using directives ,class-1 cat-egorical attributes and class-2 categorical attributes .The priming effect was significant in using directives ,while not significant in class-1 categorical attributes and class-2 categorical attributes .Conclusion The priming effect of the characteristic of the color code is significant ,and the characteristic of the color code can promote the process of memorization of the medicine for self-aid and mutual-aid .
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Objective To establish a gas chromatograph method for determing Chloroform, ethyl acetate and N, N-dimethyl formamide in butoconazole nitrate. Methods The samples was detected by Headspace Gas Chromatography. Temperature programming method was adpoted and FID was used as detector. The injector temperature was 200 ℃, and the detector temperature was reach 250 ℃. Nitrogen was used as carrier gas in the experiment. Results In the mentioned chromatographic conditions, Chloroform, ethyl acetate and N, N-dimethyl formamide had good linear relationships in the ranges of 0. 066-0. 588,0. 062-0. 556 and 0. 896-8. 061 μg·mL-1 respectively. The average recoveries were 99. 18%,102. 84% and 98. 71%. RSD were 3. 87%,4. 33% and 3. 71%. Conclusion The detection method is sensitive, accurate, reliable, and can be used as a quality control for butoconazole nitrate.
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Objective:To explore whether there will be attentional bias under the condition of fear,disgust and positive emotional arousal. Methods:Totally 96 college students were selected as participants in this study,inclu-ding 60 males and 36 femalesaged 18-22 years. Affective priming videos were adopted to prime participants'emo-tion (dread,disgust,joviality),and then they named the color of the cognitive words (positive words,negative words,neutral words)as quickly and accurately as possible. Reaction time and correctness were recorded. E-prime was adopted to write the experimental program. The reaction time for neutral words was baseline. Results:The aver-age reaction time (RT)of color-naming tasks of negative words were shorter than that of neutral words after fright-ening affective priming[(648 ±118)ms vs. (743 ±124)ms,P<0. 01]. Furthermore,the average RT of color-na-ming tasks of positive words were also shorter than that of neutral after frightening affective priming[(683 ±123) ms vs. (743 ±124)ms,P<0. 05]. The average RT of color-naming tasks of negative words were shorter than that of neutral words after disgusting affective priming[(579 ±86)ms vs. (720 ±101 )ms;P<0. 01 ]. Moreover,the av-erage RT of color-naming tasks of positive words were shorter than that of neutral words after delighted affective priming[(634 ±122)ms vs. (716 ±141)ms;P<0. 01]. Furthermore,the average RT of disgusting priming group-were shorter than the frightening priming grouptowards negative information[(579 ±86)ms vs. (648 ±118)ms,P<0. 05 ]. Conclusion:It suggests that the youth perform more obvious attentional bias towards negative information after disgusting affective priming than the frightening one. Frightening affective priming could evidently induce the attentional bias on positive information.
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OBJECTIVE:To prepare borneol-puerarin liposomes,and to investigate its brain-targeting. METHODS:Film dis-persion ultrasonic method was used to prepare borneol-puerarin liposomes. The morphology of liposomes was observed by TEM;the particle size and Zeta potential were measured by laser particle size analyzer;the entrapment efficiency were measured by sepha-dex gel filtration method. Compared with Puerarin injection,brain-targeting of borneol-puerarin liposomes and puerarin liposomes via intravenous injection of mice tail was studied with relative intake rate and peak concentration ratio. RESULTS:Borneol-puerarin liposomes were spherical or quasi-circular;its mean particle size,polydispersity index and Zeta potential were 226 nm,0.263 and-21.3 mV respectively. The entrapment efficiency were(65.32±2.13)%. Compared with Puerarin injection,relative intake rate of puerarin liposome and borneol-puerarin liposome were 1.68 and 2.58,and peak concentration ratio were 1.15 and 1.42. CONCLU-SIONS:Brain-targeted borneol-puerarin liposomes are prepared successfully.
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Objective To study the influence of exposure factors on posttraumatic stress disorder( PTSD) and Posttraumatic Growth( PTG) in middle school students in disaster area four years after the Wenchuan earth?quake . Methods 1 526 students from four schools in Worst?Hit Areas were investigated with Self?compiled Earth?quake Exposure Factors Questionnaire,Posttraumatic Growth Inventory( C?PTGI) and Impact of Event Scale( IES?R). Data were analyzed by ANOVA and multiple linear regression analysis.Results The score of IES?R had sig?nificant difference between different levels of all exposure factors(F=5.75~89.10, P<0.05) ,and students with high exposure level((26.68±14.66),(26.80±15.56),(27.83±14.62),(29.02±15.36),(27.77±15.74),(26.74± 15.63),(25.43±14.32),(29.51±14.36)) had heavier symptoms of PTSD than those with low exposure level ((22.84±13.96),(23.98±13.99),(23.63±14.21),(23.53±13.96),(23.64±13.83),(24.24±14.15),(21.27± 14.35),(17.54±13.34)). Only exposure factors of having witnessed someone injured and having close friends se?riously injured or being killed could significantly influence the score of PTGI(F=11.82, P=0.001;F=6.23, P=0.013). Regression analysis showed that five exposure factors (grade,having felt scared,having family members being killed,having close friends seriously injured or being killed,having witnessed someone injured) had signifi?cant effect on IES(ΔR 2=0.141) ,but only one factor( having witnessed someone injured) had weak effect on PTG (ΔR 2=0.007).Conclusion Exposure factors can predict posttraumatic stress symptoms in middle school students in Wenchuan four years after the earthquake,and the emotion of fear is a strongest predictor,but they can not pre?dict posttraumatic growth.
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Objective:To determine the content of chloroform, ethyl acetate and DMF in dimemorfan phosphate by gas chromatog-raphy (GC). Methods:The capillary gas chromatography was used with a PEG-20M column, programmed temperature, water as the solvent and FID as the detector. Results:The three organic solvents were separated and showed good linear relationship (r>0. 999 0). The detection limit of chloroform, ethyl acetate and DMF was 0. 63,0. 60 and 8. 92μg·ml-1 , respectively. The residues of the organ-ic solvents in three batches of the samples all met with the requirements of ICH. Conclusion: The method is sensitive, accurate and reliable, and can be used in the quality control of dimemorfan phosphate.
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Objective: To explore how the Chinese- English Bilinguals represent knowledge of the second language. Methods: The inter- language priming effects were investigated in two priming- category judgement tasks based individual- ly on the semantic (ExperimentⅠand ExperimentⅡ) and phonological information (ExperimentⅢ and ExperimentⅣ). Re- sults: In experimentⅠand ExperimentⅡ, no matter what the relation between the English targets and the English primes was semantic association or homophones and similar phones, the significant priming effects were obtained; However, In the experimentⅢ, when the relation between the targets and the primes was semantic association, no significant priming effect was found; In experimentⅣ, when the relation was homophones and similar phones, the significant priming effects were obtained. Conclusion: ①The second language knowledge of Chinese- English Bilinguals was represented in the semantic and phonological characters; ②The conceptual representation could be discreted with the lexical representation.